Exploring Processor and Memory Architectures for Multimedia

Multimedia has become one of the cornerstones of our 21st century society and, when combined with mobility, has enabled a tremendous evolution of our society. However, joining these two concepts introduces many technical challenges. These range from having sufficient performance for handling multimedia content to having the battery stamina for acceptable mobile usage. When taking a projection of where we are heading, we see these issues becoming ever more challenging by increased mobility as well as advancements in multimedia content, such as introduction of stereoscopic 3D and augmented reality. The increased performance needs for handling multimedia come not only from an ongoing step-up in resolution going from QVGA (320x240) to Full HD (1920x1080) a 27x increase in less than half a decade. On top of this, there is also codec evolution (MPEG-2 to H.264 AVC) that adds to the computational load increase. To meet these performance challenges there has been processing and memory architecture advances (SIMD, out-of-order superscalarity, multicore processing and heterogeneous multilevel memories) in the mobile domain, in conjunction with ever increasing operating frequencies (200MHz to 2GHz) and on-chip memory sizes (128KB to 2-3MB). At the same time there is an increase in requirements for mobility, placing higher demands on battery-powered systems despite the steady increase in battery capacity (500 to 2000mAh). This leaves negative net result in-terms of battery capacity versus performance advances. In order to make optimal use of these architectural advances and to meet the power limitations in mobile systems, there is a need for taking an overall approach on how to best utilize these systems. The right trade-off between performance and power is crucial. On top of these constraints, the flexibility aspects of the system need to be addressed. All this makes it very important to reach the right architectural balance in the system. The first goal for this thesis is to examine multimedia applications and propose a flexible solution that can meet the architectural requirements in a mobile system. Secondly, propose an automated methodology of optimally mapping multimedia data and instructions to a heterogeneous multilevel memory subsystem. The proposed methodology uses constraint programming for solving a multidimensional optimization problem. Results from this work indicate that using today’s most advanced mobile processor technology together with a multi-level heterogeneous on-chip memory subsystem can meet the performance requirements for handling multimedia. By utilizing the automated optimal memory mapping method presented in this thesis lower total power consumption can be achieved, whilst performance for multimedia applications is improved, by employing enhanced memory management. This is achieved through reduced external accesses and better reuse of memory objects. This automatic method shows high accuracy, up to 90%, for predicting multimedia memory accesses for a given architecture

The efficacy of resveratrol in controlling hypertension: study protocol for a randomized, crossover, double-blinded, placebo-controlled trial

Background: Hypertension is a global health concern for which novel treatment strategies are necessary. The aim of this study is to evaluate the efficacy of resveratrol (trans-3, 5, 4′-trihydroxystilbene, a polyphenol present in grapes) in controlling blood pressure in participants diagnosed with prehypertension and stage 1 hypertension. Methods/design: In a randomized, crossover, double-blinded, placebo-controlled study, 50 participants with prehypertension (diastolic blood pressure and systolic blood pressure, 80–89 mmHg and 120–139 mmHg, respectively) and 50 participants with stage 1 hypertension (diastolic and systolic, 90–99 mmHg and 140–159 mmHg, respectively) will be assigned to receive resveratrol (99 % pure, from Biotivia Longevity Bioceuticals LLC Company, USA, in 500 mg capsules, twice daily for 4 weeks, orally) or placebo (500 mg neutral microcellulose capsules, twice daily for 4 weeks) in a 2 × 2 crossover design (4 weeks treatment—4 weeks washout—4 weeks treatment). The blood pressure of each participant will be recorded (a mean of two times within a 15-minute interval) every week during the study. The participants in the prehypertensive group will not receive any medication, while those in the stage 1 hypertensive group will continue to receive their routine medications during the study. Blood samples will be taken from all groups and examined for various biochemical parameters. Discussion: This trial will help to establish whether resveratrol is an effective antihypertensive agent in prehypertensive and stage 1-hypertensive patients. The trial outcome will provide novel insight into the clinical efficacy of resveratrol and provide valuable information for conducting future clinical studies with resveratrol. Trial registration: Iranian Registry of Clinical Trials, IRCT201407078129N7. Registered on 15 August 2014. Keywords: Resveratrol, Hypertension, Blood pressure, Polyphen

Plasma malondialdehyde, bilirubin, homocysteine and total antioxidant capacity in patients with angiographically defined coronary artery disease

Oxidative stress has been implicated in coronary artery disease (CAD). Malondialdehyde (MDA) is lipid peroxidation end product. Bilirubin may act as an antioxidant that suppresses lipid oxidation. The role of MDA and antioxidant capacity and their inter-relationship in patients with and without CAD was investigated. Thirty-eight consecutive patients with angiographically diagnosed CAD were compared with 60 age, and sex-matched controls. The controls had completely normal coronary arteries in angiograms. Plasma MDA, serum bilirubin, total homocysteine and total antioxidant capacity (TAC) levels were measured. Risk factors of CAD were determined for all subjects using National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATP)-III criteria. Serum MDA and total homocysteine concentration were significantly higher, but TAC, total bilirubin and direct bilirubin levels were lower in CAD patients when compared to the controls. Age, and sex-adjusted plasma MDA levels had negative correlations with TAC (r = -0.30, p = 0.001) and total bilirubin (r = -0.30, p = 0.002) concentrations. In multivariate analysis by the multiple logistic regression method, serum MDA was significantly associated with CAD (OR = 1.15, 95% CI, 1.25 to 1.82; p < 0.0001)) after adjustment for lipid status parameters and traditional risk factors in this study population. Increased serum MDA concentration, as a biomarker of lipid peroxidation, low serum bilirubin and antioxidant capacity were observed in patients with angiographically defined CAD. The significant inverse correlation of the serum bilirubin and MDA levels demands further in-depth investigations to clarify the association between them in the development of CAD

The Effect of Educational Intervention based on the Health Belief Model on Diabetes Screening Behavior in over 30 Years Old men in Shahr-e-Babak

Background: Diabetes is one of the major health problems in the world and half of the affected patients are unaware of it. The aim of this study was to determine the effect of the Health Belief Model on the behavior of male subjects attending diabetes screening. Methods: This interventional study was performed on 180 men over 30 years of age. The intervention group (90 ones) underwent educational intervention conducted over four 60-minute sessions. Data were collected using a questionnaire (including 51 questions) filled out through direct interview before the intervention and two months after that. Fisher's exact test, Wilcoxon and Mann-Whitney tests were used for data analysis. Results: After the intervention, knowledge scores increased in both intervention and control groups. This was due to the implementation of routine training at the centers. But, significant increase in the attitudes and practice was observed only in the intervention group. Also, perceived benefits, perceived barriers, and cues to action, after the intervention, showed significant increase in the intervention group compared with the control group (P <0.001). Conclusion: Health Belief Model was effective in education of people over 30 years old for participating in diabetes screening programs. Therefore, it is recommended to use this model alongside traditional methods

Development of Risk-Taking Tendency Tool for High School Students

Background: Adolescence is the age of increased sensation-seeking and risk-taking. To prevent such behaviors, the adolescent tendency to engage in high-risk behaviors must be measureable. This study aimed to develop a questionnaire about risk-taking tendencies among Iranian students.Methods: This study was conducted using cluster sampling of the tenth-grade students in three cities in Kerman province, Iran. The students were assured that the questionnaires would remain anonymous and unlinked. Construct validity was assessed using exploratory factor analysis (EFA) and comparison of known groups. Corrected item-scale correlation and Cronbach's alpha were calculated to evaluate reliability.Findings: A total of 551 high school students participated in this study. Of these, 57 were excluded after checking the “non-existent drug” item (10.3%). Girls accounted for 49.2% of the sample. Of the 33 initial questions, 13 were removed due to factor loading of less than 0.5. Two factors were extracted using the scree plot (“drug abuse tendency" and "other risky behavior tendency"). The tendency toward high-risk behavior was significantly higher in male students than in female ones (P < 0.001). This indicates the known group validity of the questionnaire. The Cronbach's alpha of the above-mentioned factors were 0.93 and 0.83, respectively.Conclusion: The questionnaire measuring the tendency toward high-risk behavior among students showed acceptable validity and reliability

Data on copper level in the blood of patients with normal and abnormal angiography

In this data article, we measured the levels of copper in the blood of patients undergoing coronary angiography. The samples were taken from patients with cardiovascular disease in Bushehr's university hospital, Iran. Patients were divided in two groups: normal angiography and abnormal angiography. After the chemical digestion of samples, the concentration levels of Cu in both groups were determined by using inductively coupled plasma optical spectrometry (ICP-OES). & 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY licens

Factors Effective on Drug Abuse from the Male Prisoners Point of View: Case Study of One of the Southeastern Prisons in Iran

Background: Identifying the factors effective on the tendency to substance use from the viewpoint of high-risk groups such as prisoners is essential for planning to control and prevent substance use. The purpose of this study was to determine the factors related to substance use tendency from the prisoners' point of view. Methods: This descriptive and analytic cross-sectional study was performed in the winter of 2015 on male prisoners in one of the southeastern prisons of Iran. Subjects were enrolled by simple random sampling based on the list of prisoners. The questionnaire included demographic characteristics, substance use, factors effective on substance abuse tendency in the individual, interpersonal and social domains. Finally, Data was analyzed using SPSS 20 software with two sample t-test, one-way ANOVA and Tukey post hoc tests. Results: The social (mean score 3.67) and individual (mean score 3.56) domains had the highest, and interpersonal domains (mean score 3.48) had the lowest mean scores for the factors affecting substance use tendency. The mean scores of each three domains were significantly different (P<0.001). In the individual domain, a positive attitude towards substance use (3.84), in the social domain, lack of access to counseling services (3.72) and in the interpersonal domain, the friends' component (3.64) had the highest mean scores. Conclusion: Providing supportive and counseling services, limiting access to drugs, changing attitudes about drug use and treatment, and preventing depression should be considered as a basis for substance use prevention program

Pattern of Substance Use and Related Factors in Male Prisoners

Background: Prisoner’s addiction is one of the major problems in many countries which imposes very high medical costs and social harm to communities. This study investigated the pattern of substance use and related factors in male prisoners in one of the prisons in southeastern Iran.Methods: This cross-sectional study was carried out in 2016. The study population was inmates of a prison in southeast Iran. Sampling was carried out randomly according to the list of prisoners. Data were collected using a form and were analyzed with statistics software SPSS.Findings: More than four-fifths (75.3%) of the subjects consumed at least one substance (alcohol, tobacco and other drugs), 74.4% were smoking, 73.2% used a narcotic substance, and about one-fifth (19.3%) reported drinking alcohol. With a frequency of 62.0%, opium was the most frequently utilized narcotic substance. Poppy juice (31.6%), cannabis (29.8%), crystal (16.9%) and tramadol (16.9%) were the next frequent substances used. A percentage of 41.5% subjects reported using two or more drugs. A percentage of 80.7% subjects reported substance use among their friends, 39.2% by siblings and 37.2% by father. Regression analysis showed predictor variables of substance use were education, substance use by prisoner before being imprisoned, substance use by father, friends and siblings.Conclusion: This study showed a remarkable prevalence of substance use in prisons, which was more than general population. Therefore, it is necessary to consider alternative penalties of imprisonment due to the factors associated with substance use. Screening of people at high risk for substance use should be considered on admission to prison, and primary prevention measures should be focused on them

Comparison of 180° and 360° Arc Data Acquisition to Measure Scintigraphic Parameters from Gated Single Photon Emission Computed Tomography Myocardial Perfusion Imaging: Is There Any Difference?

Objective: The aim of the current study was to compare 180° and 360° data collection modes to measure end diastolic volume (EDV), end systolic volume (ESV) and ejection fraction (EF) values of the cardiac system by gated myocardial perfusion tomography. Methods: Thirty-three patients underwent gated myocardial perfusion tomography. Single photon emission computed tomography data of patients’ heart were acquired by 180°, 45° left posterior oblique to 45° right anterior oblique, and 360° to obtain EDV, ESV, EF and cardiac volume changes (V1, V2, V3, V4, V5, V6, V7 and V8) throughout each cardiac cycle. Results: Results of the current study indicated that there were no significant differences between 180° and 360° angular sampling in terms of measuring EDV, ESV and EF in myocardial perfusion imaging. Cardiac volume change patterns during a cardiac cycle were also similar in 360° and 180° scans. We also observed that there was no difference in EDV, ESV and EF values between the group with stress induced by exercise and the group with stress imposed by dipyridamole. Conclusion: As there is no difference between 180°and 360° cardiac scanning in terms of EDV, ESV and EF, half-orbit scan is recommended to study these cardiac system parameters because it offers more comfort to patients and a shorter scanning time. Keywords: 180° data collection, 360° data collection, ejection fraction, end diastolic volume, end systolic volume, gated myocardial perfusio

The efficacy of resveratrol in controlling hypertension: study protocol for a randomized, crossover, double-blinded, placebo-controlled trial

Abstract Background: Hypertension is a global health concern for which novel treatment strategies are necessary. The aim of this study is to evaluate the efficacy of resveratrol (trans-3, 5, 4′-trihydroxystilbene, a polyphenol present in grapes) in controlling blood pressure in participants diagnosed with prehypertension and stage 1 hypertension. Methods/design: In a randomized, crossover, double-blinded, placebo-controlled study, 50 participants with prehypertension (diastolic blood pressure and systolic blood pressure, 80–89 mmHg and 120–139 mmHg, respectively) and 50 participants with stage 1 hypertension (diastolic and systolic, 90–99 mmHg and 140–159 mmHg, respectively) will be assigned to receive resveratrol (99 % pure, from Biotivia Longevity Bioceuticals LLC Company, USA, in 500 mg capsules, twice daily for 4 weeks, orally) or placebo (500 mg neutral microcellulose capsules, twice daily for 4 weeks) in a 2 × 2 crossover design (4 weeks treatment—4 weeks washout—4 weeks treatment). The blood pressure of each participant will be recorded (a mean of two times within a 15-minute interval) every week during the study. The participants in the prehypertensive group will not receive any medication, while those in the stage 1 hypertensive group will continue to receive their routine medications during the study. Blood samples will be taken from all groups and examined for various biochemical parameters. Discussion: This trial will help to establish whether resveratrol is an effective antihypertensive agent in prehypertensive and stage 1-hypertensive patients. The trial outcome will provide novel insight into the clinical efficacy of resveratrol and provide valuable information for conducting future clinical studies with resveratrol. Trial registration: Iranian Registry of Clinical Trials, IRCT201407078129N7. Registered on 15 August 2014. Keywords: Resveratrol, Hypertension, Blood pressure, Polypheno